Dr. Sergio Abonante
Niacin activates the G protein estrogen receptor (GPER)-mediated signalling
G protein-coupled receptors (GPCRs) are cell-surface proteins involved in multiple pathophysiological responses including cancer. Increasing evidence has demonstrated that theG protein-coupled estrogen receptor, named GPER/GPR30mediates diverse biological effects induced by a wide number of compounds like estrogens, anti-estrogens and environmental contaminants in normal and malignant cells. GPER mediates rapid events that activate diverse transduction pathways leading to a characteristic gene signature involved in important biological functions
