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GPER activates Notch signaling in breast cancer

GPER activates Notch signaling in breast cancer cells and cancer-associated fibroblasts (CAFs) The G protein-coupled receptor GPR30/GPER has been shown to mediate rapid effects of 17-estradiol (E2) in diverse types of cancer cells. Here, we provide evidence for a novel crosstalk between GPER and the Notch signaling pathway in breast cancer cells and …

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Breast Cancer and Venous Disease: A Retrospective Cohort Study

Breast cancer (BC) and chronic venous disease (CVD) are in some way related to hormonal effects, and often the clinical manifestations of CVD intersect with the clinical course of BC. This article describes the correlations between these clinical conditions. A total of 1138 female patients with BC were retrospectively reviewed in a 5-year …

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The nuclear localization signal is required for nuclear GPER

The nuclear localization signal is required for nuclear GPER translocation and function in breast Cancer-Associated Fibroblasts (CAFs) Cancer associated fibroblasts (CAFs) actively contribute to the growth and invasion of cancer cells. In recent years, the G protein estrogen receptor (GPER) has been largely involved in the estrogenic signals in diverse types of normal and …

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Skin-Sparing Mastectomy with Immediate Breast and Nipple Reconstruction

Skin-Sparing Mastectomy with Immediate Breast and Nipple Reconstruction: A New Technique of Nipple Reconstruction Most women with breast cancer today can be managed with breast conservation; however, some women still require mastectomy for treatment of their disease. Skin-sparing mastectomy (SSM) with immediate reconstruction has emerged as a favorable option for many of these patients. …

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G Protein-coupled Estrogen Receptor Mediates

G Protein-coupled Estrogen Receptor Mediates the Up-regulation of Fatty Acid Synthase Induced by 17 -Estradiol in Cancer Cells and Cancer-associated Fibroblasts Activation of lipid metabolism is an early event in carcinogenesis and a central hallmark of many tumors. Fatty acid synthase (FASN) is a key lipogenic enzyme catalyzing the terminal steps in the de …

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Bisphenol A Induces Gene Expression Changes

Bisphenol A Induces Gene Expression Changes and Proliferative Effects through GPER in Breast Cancer Cells and Cancer-Associated Fibroblasts Bisphenol A (BPA), used largely in the manufacture of polycarbonate plastics, is the constituent of a wide array of consumer products, including plastic food containers, baby bottles, and the lining of metal food cans (Welshons et al. 2006). …

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